Trimethyltin and cancer

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August undefined, 2024

WebTrimethyltin (TMT) is an organotin compound exhibiting neurotoxicant effects selectively localized in the limbic system and especially marked in the hippocampus, in both experimental animal models and accidentally exposed humans. TMT administration causes selective neuronal death involving either the granular neurons of the dentate gyrus or the … WebMay 18, 2024 · They occur in less than 2% of cases and may include: daytime sleepiness headache dizziness hypothermia (low body temperature) It’s important to keep in mind …

ATSDR Tin ToxFAQs - Agency for Toxic Substances and …

WebMar 1, 2024 · Trimethyltin induces apoptosis and necroptosis of mouse liver by oxidative stress through YAP phosphorylation. Yuqi Wang, Xiaojing Liu, Hongyuan Jing, ... PGRMC1 Promotes Progestin-Dependent Proliferation of Breast Cancer Cells by Binding Prohibitins Resulting in Activation of ERα Signaling. Ying Bai, M. Ludescher, +13 authors H. Neubauer ... Web*Trimethyltin Chloridemay cause mutations (genetic changes). Whether or not it poses a cancer or reproductive hazard needs further study. Reproductive Hazard *Trimethyltin … milwaukee advertising firms

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WebTrimethyltin and methyl mercury are both neurotoxicants that also have ototoxic properties. Of note is the fact that the chemically related triethyltin is a neurotoxicant but not an … WebNational Center for Biotechnology Information WebApr 6, 2024 · NiCl 2, a compound containing nickel, is extremely toxic to both humans and laboratory animals ( 1 ). Studies have shown that exposure to NiCl 2 is carcinogenic. NiCl 2 have the potential to cause cancer through various mechanisms, including oxidative stress, genomic DNA damage, epigenetic changes, and activation of transcription factors ( 2 ). milwaukee age discrimination lawyer

Toxicity of trimethyltin and triethyltin to mallard ducklings

WebFeb 22, 2024 · Trimethyltin (TMT) is a potent neurotoxicant that affects various regions within the central nervous system, including the neocortex, cerebellum, and hippocampus. In the present study, ginsenoside Rd was investigated as a candidate neuroprotective agent in a primary hippocampal neuron culture and mouse models. TMT induced neurotoxicity in a … WebTrimethyltin (TMT) is an environmental neurotoxin that mediates dopaminergic neuronal injury in the brain. In this study, we characterized the toxic mechanism and possible protective compounds against TMT-induced neurotoxicity in human dopaminergic neuroblastoma SH-SY5Y cells. Antioxidants such as melatonin, N-acetylcysteine (NAC), α … milwaukee ago chapterWebJun 11, 2024 · Trimethyltin (TMT) is an organotin compound that is considered a potent neurotoxicant and causes behavioral alterations as well as learning and memory impairment in mammals [5, 6]. Cognitive impairment, including memory loss and learning impairment, developed in experimental animals exposed to TMT, indicating severe hippocampal … milwaukee agents south africa

"WebApr 11, 2024 · Ginsenoside compound K has been proven to have a range of anti-cancer activities against lung cancer, leukemia, breast cancer, and colon cancer [8,9,10,11]. Ginsenoside Rh2 shows anti-cancer activity against lung cancer and liver cancer by mediating the apoptosis of cancer cells and suppressing cell proliferation and migration [ … " - Trimethyltin and cancer

Trimethyltin and cancer

Chemotherapy for breast cancer - Mayo Clinic

WebOct 7, 2011 · TRIM24 is a potent liver-specific tumour suppressor in mice and attenuates RARα-mediated transcription. TRIM28 (also known as TIF1β and KAP1) is highly … Weborganotins, such as trimethyltin and triethyltin compounds, can interfere with the way the brain and nervous system work. In severe cases, it can cause death. ... There is no evidence that tin or tin compounds cause cancer in humans. Studies in animals have not shown evidence of carcinogenicity for inorganic tin. A study in rats and another

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WebTrimethyltin is an intermediate by-product in the production of other more commonly used tin products. 3 It, ... Case Study 39: Residential Radon Exposure and Lung Cancer in Sweden 695–700; Case Study 40: Community Oubreaks of Asthma Associated with Inhalation of Soybean Dust 701–706; WebJun 16, 2010 · Trimethyltin chloride (TMTC) and triethyltin chloride (TETC) were fed to mallard (Anas platyrhynchos) ducklings for 73 to 75 d, beginning when ducklings were 3 to 4 d old. Diets were mixed to contain 0,0.5,5 or 50 ppm Sn as either TMTC or TETC. Mortality occurred only in the 5 ppm (2/5 ducklings) and 50 ppm (5/5 ducklings, all dying within 5 d) …

WebThere is no evidence that tin or tin compounds cause cancer in humans. Studies in animals have not shown evidence of carcinogenicity for inorganic tin. A study in rats and another in mice showed that a specific organotin, triphenyltin hydroxide, can produce cancer in animals after long-term oral administration. WebOct 6, 2024 · Chemotherapy as the primary treatment for advanced breast cancer. If breast cancer has spread to other parts of your body and surgery isn't an option, chemotherapy …

WebInstitute of Cancer Research (ICR) mice were fed a control or a methoxsalen-supplemented diet for 4 weeks, and then learning and memory enhancing eﬀects with respect to trimethyltin (TMT)-induced neurotoxicity were evaluated. The brain tissues of ICR mice were dissected after completion of the behavioral tests for biochemical analysis. WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. It preferentially affects the outer hair cells of the basal cochlea. Trimethyltin will produce …

WebDAPI染色液 (DAPI Staining Solution)是经过精心优化几乎适用于所有常见细胞和组织细胞核染色的染色液。. DAPI，即2- (4-Amidinophenyl)-6-indolecarbamidine dihydrochloride，也称DAPI dihydrochloride，分子式为C 16 H 15 N 5 ·2HCl ，分子量为350.25 ，CAS Number 28718-90-3。. DAPI是一种可以穿透细胞 ...

WebTrimethyltin-induced hippocampal neurodegeneration: A mechanism-based review 2016 Jul;125:187-99. doi: 10.1016/j.brainresbull.2016.07.010. Epub 2016 Jul 20. Authors Sueun Lee 1 , Miyoung Yang 2 , Jinwook Kim 1 , Sohi Kang 1 , Juhwan Kim 1 , Jong-Choon Kim 1 , Chaeyong Jung 3 , Taekyun Shin 4 , Sung-Ho Kim 1 , Changjong Moon 5 Affiliations milwaukee air conditioner window unitWebJul 1, 2024 · Trimethyltin chloride (TMT) is a by-product in the synthesis of organotin, a plastic stabilizer. With the rapid development of industry, the occupational hazards caused by TMT cannot be ignored. ... Cytotoxicity in vitro of compounds has been estimated on human cancer (colon cancer HCT-116, lung carcinoma A549, breast cancer MCF-7 ... milwaukee aging and disability resourceWebMay 22, 2024 · Trimethyltin (TMT) is produced as a byproduct during this synthesis and it is more toxic than MMT and DMT. Methyltin-stabilized PVC is used in packaging, piping, coating, and window frames ( 1 ). OTs have been found to leach from PVC pipes and it can contaminate foodstuffs, beverages, drinking water, and sewage ( 3, 4 ). milwaukee agency on agingWebMalignant gliomas are the most common primary brain tumors in humans. However, poor response to conventional therapeutic approaches, including chemotherapy, leads invariably to disease recurrence and progression. The organo–tin derivative triethyltin(IV)lupinylsulfide hydrochloride (IST-FS 29) was identified and developed as potential antiproliferative agent … milwaukee airbnb with hot tubWebOct 19, 2024 · Three aromatase inhibitors are currently approved in the United States for breast cancer treatment: anastrozole (Arimidex), exemestane (Aromasin) and letrozole … milwaukee air compressor hoseWebThe present study examined the involvement of purinergic signaling components in the rat model of hippocampal degeneration induced by trimethyltin (TMT) intoxication (8 mg/kg, single ... milwaukee air blower m18WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. Like many other ototoxicants, it preferentially affects the outer hair cells of the basal (high-frequency) areas of the cochlea. Electrophysiological changes in the compound action potential can be detected within minutes. milwaukee airfare deals