Phosphatase tensin-type domain

Author: jucv

August undefined, 2024

Webphosphatase and tensin homolog, b-catenin, p53, endometrial carcinoma. C ancer of the uterine corpus is the most common gynecologic malignancy in the U.S., with approximately 40,880 cases diag-nosed in 2006.1 The incidence of endometrial carcinoma (EC) also has risen each year in Japan over 30 years from 10% in 1983 to 45% WebDescription: Homo sapiens transmembrane phosphatase with tensin homology (TPTE), transcript variant 1, mRNA. (from RefSeq NM_199261) RefSeq Summary (NM_199261): …

PTEN phosphatase and tensin homolog [ (human)]

WebJul 9, 2024 · • Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual phosphatase with both protein and lipid phosphatase activities. • PTEN reduces the level of PI-3, 4, 5-P 3, a critical 2nd … WebAug 26, 2024 · The importance of phosphatase and tensin homolog deleted on chromosome ten ( PTEN) in tumorigenesis is underscored by its frequent mutations, … i/o architecture of a computer system

Recombinant Anti-PTEN antibody [EPR9941] (ab154812)

WebMar 1, 2024 · β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models Overall, we delineate a molecular cascade presenilins-AICD-Forkhead box O3a linking parkin to Pink-1. WebMar 21, 2024 · The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. ... interacts (via C2 tensin-type domain) with p85 but, following growth factor stimulation, PTEN is … WebGene Variant Descriptions. PTEN H93Q lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Q demonstrates Pten protein stability similar to wild-type protein ( PMID: 32350270, PMID: 32366478 ), however, results in a partial loss of ability to rescue spheroid formation ( PMID: 32366478 ), fails to suppress Akt ... onset of action prazosin

PTENα functions as an immune suppressor and promotes …

UniProt

WebSMART: PTEN_C2 domain annotation PTEN_C2 C2 domain of PTEN tumour-suppressor protein There are 6056 PTEN_C2 domains in 6045 proteins in SMART's nrdb database. Click on the following links for more information. Evolution (species in which this domain is found) Cellular role (predicted cellular role) Structure (3D structures containing this domain) Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been … See more PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the See more The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right ) reveals that it consists primarily of a phosphatase domain, and a C2 domain: the phosphatase domain contains the active site, which carries out the See more PTEN inhibitors Bisperoxovanadium compounds may have a neuroprotective effect after CNS injury. PTEN is inhibited by See more PTEN (gene) has been shown to interact with: • CSNK2A2, • CSNK2A1, • MAGI3 • MVP, • NEDD4, See more Cancer PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. A number of studies … See more Cell lines with known PTEN mutations include: • prostate: LNCaP, PC-3 • kidney: 786-O • glioblastoma: U87MG • breast : MB-MDA-468, BT549 See more • Multiple hamartoma syndrome See more onset of action of valsartanWebJan 1, 2009 · Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor and bi-functional lipid and protein phosphatase. We report that the metabolic regulator pyruvate dehydrogenase kinase1 (PDHK1) is a synthetic-essential gene in PTEN-deficient cancer and normal cells. onset of a disease

"WebMar 28, 1997 · In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma cell lines and xenografts, 100% (4/4) of prostate cancer cell lines, 6% (4/65) … " - Phosphatase tensin-type domain

PTEN phosphatase and tensin homolog [ (human)]

Recombinant Anti-PTEN antibody [EPR9941] (ab154812)

Phosphatase tensin-type domain

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