Jph2 molecular weight
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic membrane occupa… Nettet15. des. 2016 · Background: Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 …
Jph2 molecular weight
Did you know?
NettetUseful information about the protein provided by UniProt. [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcopl asmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes 1. Provides a structural foundation for functional cross-talk between the ... NettetMethods and Results—JPH2 expression was reduced in flash-frozen human cardiac tissue procured from patients with HCM compared with ostensibly healthy traumatic death victims. Partial silencing of JPH2 expression in HL-1 cells by a small interfering RNA probe targeted to murine JPH2 mRNA (shJPH2) resulted in myocyte hypertrophy and increased
Nettet7. okt. 2024 · Protein lysates from whole cerebral arteries and hearts probed with a primary antibody against JPH2 produced bands at the predicted molecular weight of the protein … NettetSCPH2. Classification: Casting steel Carbon steel. Standards: JIS G 5151 : Steel castings for high temperature and high pressure service. Applications: Steel castings for high …
NettetJPH2 Protein Molecular Weight & PI The parameters have been computed for the following feature FT CHAIN 1-696 Junctophilin-2. Molecular weight (Da) 74221.56 … Nettet24. mar. 2009 · In skeletal muscle, junctophilin-1 (JPH1) is believed to facilitate direct protein-protein interactions between voltage-dependent L-type Ca 2+ channels (LTCC) on the PM and intracellular Ca 2+ release channels (CRCs), specifically the type 1 ryanodine receptor (RyR1), on the SR (36, 40).In cardiac muscle, JPH2 determines the distance …
Nettet15. jun. 2014 · Mice with cardiac-specific shRNA-mediated knockdown of JPH2 were unable to form mature T-tubules within the first few weeks of life, while Bin1 levels remained unchanged. 14, 16 Conversely, T-tubule maturation occurred earlier in mice overexpressing JPH2 (Figure 1). 14 The disruption in maturation preferentially affected …
NettetKnow comprehensive JPH2 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction. incontinence laser surgery for womenNettetThe molecular weight distribution (MWD) is conveniently characterized by either the number N(n) or weight W(n) of chains with n repeating units (e.g., a chain with molecular weight M = nm0 with m0 the molar weight of a repeating unit). The normalized functions N — (n) = N(n)/ΣN(n) (1) N — (n) = W(n)/ΣW(n) (2) respectively, are the number ... incipit ferragus balzacNettet13. aug. 2012 · Several molecular mechanisms have been shown to contribute to downregulation of JPH2 expression levels in failing hearts (28,272). First, the mouse, rat, and human homologues of JPH2 are... incipit inverseNettet9. aug. 2010 · Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the organization of the junctional membrane complex (JMC) in cardiac myocytes. JPH2 is believed to keep the plasma ... incipit huis closNettet17. jan. 2003 · HGNC:14202 JPH2 MIM 605267 gene 613873 phenotype 619492 phenotype VEuPathDB HostDB:ENSG00000149596 neXtProt NX_Q9BR39 Subcellular … incipit le horla texteNettet26. jun. 2024 · Based on western blotting, the molecular weight of JPH2-CTP is estimated to exceed 20 kDa, hence the C-terminal domain is excluded (see 2). The domain … incontinence leakingNettet2. mar. 2024 · This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008] Expression. Biased expression in heart (RPKM 14.9), … incontinence laser treatment