WebHere we report that targeting increased replication stress with a combination of Checkpoint kinase 1 inhibitor (CHK1i) with a subclinical dose of hydroxyurea targets also promotes pro-inflammatory... WebMar 17, 2014 · We find that STAT3 interrupts ATR-to-Chk1 signaling by promoting loss of Claspin, a protein that assists ATR to phosphorylate Chk1. This loss of Claspin which ultimately facilitates cell proliferation is mediated by caspase 7, a protein that typically promotes cell death.
When cells sense the cue for growth - phys.org
WebFeb 23, 2024 · ChK1-mediated CIP2A overexpression drives inhibition of PP2A and activates STAT3, then leads to reactive astrogliosis and neurodegeneration in vitro. Infection of mouse brain with GFAP-ChK1-AAV induced AD-like cognitive deficits and exacerbated AD pathologies in vivo. WebFeb 23, 2024 · ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease Ying Zhou, Ying Zhou Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China Search for more papers by this author Xiaoyuan Liu, Xiaoyuan Liu Wenzhou Medical University, Wenzhou, China fishing spots in bangalore
DNA double-strand break repair pathway regulates PD …
WebMay 4, 2024 · Here, we show that constitutive CHK1 expression in GBM activates a recursive pSTAT3-CIP2A oncogenic circuit that drives tumor growth. Inhibition of this circuit retards GBM growth in heterotopic and orthotopic transplants and prolongs survival. Materials and Methods Cell lines and culture WebSpecifically, STAT3 interrupts ATR-to-Chk1 signaling by promoting loss of Claspin via caspase 7. These findings not only demonstrate how EBV exploits host STAT3 to interrupt DDR-signaling and drive cell proliferation past the S phase, but also reveal a function for STAT3 in regu- WebJun 10, 2024 · Here, we identified that irradiated CRC cells utilized the ataxia-telangiectasia and Rad3-related (ATR)-mediated DNA double-strand break repair pathway to upregulate CD47 and PD-L1. These then interacted with SIRPα and PD-1, respectively, to suppress phagocytosis and TAA cross-presentation by APCs. cancel spousal sponsorship canada