Cenpf cancer

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August undefined, 2024

WebFeb 5, 2024 · The expression peak of CENPF is in the cell cycle of the G2/M phase. The aberrant expression of CENPF has been found in multiple malignancies, including … WebCENPF, CENPE, CENPU, CENPA, and CENPM were the most commonly reported CENPs in breast cancer datasets. Figure 2 The mRNA expression levels of CENPs in different …

CENPF promotes the proliferation of renal cell carcinoma

WebJul 9, 2024 · CENPF protein has a broad expression in multiple tissues, such as the testis, bone marrow and lymph node . CENPF is also highly expressed in several types of human tumors, such as breast cancer, pancreatic carcinoma and prostate cancer and has been identified as a protein marker for tumor cell proliferation (9,10). To the best of our … WebJan 24, 2024 · Based on these genes, we constructed and validated a 5-gene prognostic signature (including ACADM, CENPF, KDELC1, PLOD2, and TRMT1) to distinguish low- and high-risk KIRC patients of poor survival in TCGA and E-MTAB-1980 cohorts. land for sale in pendleton county wv

IJMS Free Full-Text Deciphering the Prognostic and …

WebFeb 5, 2024 · CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle The result points out that CENPF is significantly overexpressed in ACC patients. The overexpressed CENPF predicts a poor prognosis of ACC and might augment the progress of ACC. WebMar 3, 2024 · As one of the biomarkers for CAFs, CENPF can promote the proliferation ability of prostate cancer cells. The overexpress of CENPF could promote the proliferation ability of prostate cancer cells. In conclusion, we discuss the potential prognostic and therapeutic value of CAF-dependent pathways in prostate cancer. Introduction WebOct 6, 2024 · Cervical cancer (CC) is the fourth most common female malignancy worldwide. More than half a million women are diagnosed with cervical cancer and the … land for sale in penelope texas

CENPF Gene - GeneCards CENPF Protein CENPF Antibody

CENPF centromere protein F - NIH Genetic Testing Registry …

WebProduct name Anti-CENPF antibody See all CENPF primary antibodies Description Rabbit polyclonal to CENPF Host species Rabbit Tested applications Suitable for: IHC-P more details Species reactivity Reacts with: Human Predicted to work with: Chimpanzee, Gorilla, Orangutan Immunogen Synthetic peptide: WebFeb 28, 2024 · It is critical to develop new effective clinical biomarkers and drug targets in RCC. Several studies have shown that centromere protein F (CENPF), a microtubule binding protein, promotes cancer progression in various types of cancer. The purpose of this study was to explore the role of CENPF in RCC. land for sale in pend oreille countyWebJan 31, 2024 · CENPF has been found to be overexpressed in various malignant tumours, such as prostate cancer, breast cancer, and nasopharyngeal carcinoma, and to activate … help with down payment on home

"WebApr 10, 2024 · In particular, CENPF overexpression is significantly associated with tumor metastasis and poor prognosis of hepatocellular carcinoma or breast cancer patients … " - Cenpf cancer

Cenpf cancer

Centromere protein F promotes progression of …

WebFeb 28, 2024 · • CENPF is a potential oncogene and prognostic marker in RCC, which can be used as an independent prognostic factor. Introduction Other Section Renal cell carcinoma (RCC) is the ninth most common cancer worldwide. It is estimated that there were more than 337,000 new cases diagnosed in 2012. WebCentromere protein F is a protein that in humans is encoded by the CENPF gene. [5] [6] [7] It is involved in chromosome segregation during cell division. It also has a role in the orientation of microtubules to form cellular cilia. [8] [9] Function [ edit]

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WebFeb 24, 2024 · Centromere protein F (CENPF), a member of centromere proteins and a transient kinetochore protein, regulates various cellular processes such as cell migration and mitosis, and its upregulation has been observed in multiple types of cancer, including breast cancer and gastric cancer. WebCENPF(KO) cells had reduced global bio-energetic capacity, acetyl-CoA production, histone acetylation, and lipid metabolism, suggesting that CENPF is a critical regulator of cancer …

WebFeb 7, 2024 · MiR-1-3p targets CENPF to repress tumor-relevant functions of gastric cancer cells. Zhou S, Han H, Yang L, Lin HZhou S, et al. BMC Gastroenterol, 2024 Mar 28. PMID 35346060 CENPF as an independent prognostic and metastasis biomarker corresponding to CD4+ memory T cells in cutaneous melanoma. Web(A) CENPA is more highly expressed in ovarian cancer tissues than in normal tissues (*P<0.05). (B) CENPF is more highly expressed in ovarian cancer tissues than in normal …

WebMar 20, 2024 · Among CENP family genes, CENPF and CENPE are mutated at high frequencies in various tumors, while CENPM and CENPA are less frequently mutated. Furthermore, CENPs regulate the tumor mutational burden, stemness, and microsatellite instability, and are associated with tumor immunity. WebOct 11, 2024 · The role of CENPF in breast cancer (BC) bone metastasis remains unclear. Methods Using the ONCOMINE database, we compared the expression of CENPF in breast cancer and normal tissues. Findings were confirmed in 60 BC patients through immunohistochemical (IHC) staining.

WebSep 22, 2024 · The expression of CENPF has been detected in different cancers, however its expression pattern differs among various types of cancer. These diverse observations …

WebHepatocellular carcinoma (HCC) is one of the deadliest cancer types worldwide. The centromere proteins (CENPs) are critical for the mitosis-related protein complex and are … help with downpayment for houseWebOct 11, 2024 · Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer Abstract. Centromere Protein F (CENPF) associates with the centromere–kinetochore complex and influences cell... Background. Breast cancer (BC) … help with down payment on a homeWebSep 30, 2024 · Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a low 5-year survival rate. The heterogeneity of HCC makes monotherapy unlikely. The development of diagnostic programs and new treatments targeting common genetic events in the carcinogenic process are providing further insights into the … help with downsizing for seniorsWebBy searching GEO and TCGA database, we found that CENPF was upregulated in breast cancer tissues. Through RT-qPCR, CENPF was found to be upregulated in breast cancer cells. Functional experiments revealed that CENPF had positive effect on the cellular functions, including proliferation, migration and invasion. help with drinking nhsWebFeb 21, 2024 · CENPF was shown to promote the proliferation and migration of HCC cells 16 and accelerate bone metastasis of breast cancer. 21 Additionally, CENPF … help with driving lessons for single parentsWebCentromere protein F is a protein that in humans is encoded by the CENPF gene. [5] [6] [7] It is involved in chromosome segregation during cell division. It also has a role in the … help with downsizingWebNomogram indicated CENPF clinical predictive value for 1-, 3-, 5-, and 7-year melanoma overall survival. Therefore, CENPF plays a vital role in the progression and … help with dresses guy